Germline Brca1 and Brca2 Mutations in the Australian Ovarian Cancer Study (Aocs)

Risk Factors for Ovarian Cancer by BRCA Status: A Collaborative Case-Only Analysis

K Gersekowski, R Na, K Alsop, R Delahunty, EL Goode, JM Cunningham, SJ Winham, PDP Pharoah, H Song, PM Webb

2024-04-01

Background: Women with an inherited pathogenic variant in BRCA1 or BRCA2 have a greatly increased risk of developing ovarian cance..

Germline BRCA variants, lifestyle and ovarian cancer survival

K Gersekowski, R Delahunty, K Alsop, EL Goode, JM Cunningham, SJ Winham, P Pharoah, H Song, S Jordan, S Fereday, A DeFazio, M Friedlander, A Obermair, PM Webb

2022-06-01

Objective: Women with ovarian cancer who have a pathogenic germline variant in BRCA1 or BRCA2 (BRCA) have been shown to have bette..

Homologous recombination DNA repair pathway disruption and retinoblastoma protein loss are associated with exceptional survival in high-grade serous ovarian cancer

DW Garsed, K Alsop, S Fereday, C Emmanuel, CJ Kennedy, D Etemadmoghadam, B Gao, V Gebski, V Gares, EL Christie, MCA Wouters, K Milne, J George, AM Patch, J Li, GM Arnau, T Semple, SR Gadipally, YE Chiew, J Hendley

2018-02-01

Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dra..

Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene

E Dicks, H Song, SJ Ramus, E Van Oudenhove, JP Tyrer, MP Intermaggio, S Kar, P Harrington, DD Bowtell, MS Cicek, JM Cunningham, BL Fridley, J Alsop, M Jimenez-Linan, A Piskorz, T Goranova, E Kent, N Siddiqui, J Paul, R Crawford

2017-02-07

We analyzed whole exome sequencing data in germline DNA from 412 high grade serous ovarian cancer (HGSOC) cases from The Cancer Ge..

Germline mutations in the BRIP1, BARD1, PALB2, and NBN genes in women with ovarian cancer

SJ Ramus, H Song, E Dicks, JP Tyrer, AN Rosenthal, MP Intermaggio, L Fraser, A Gentry-Maharaj, J Hayward, S Philpott, C Anderson, CK Edlund, D Conti, P Harrington, D Barrowdale, DD Bowtell, K Alsop, G Mitchell, MS Cicek, JM Cunningham

2015-11-01

Background: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in..

Connecting patients, researchers and clinical genetics services: The experiences of participants in the Australian ovarian cancer study (AOCS)

A Crook, L Plunkett, LE Forrest, N Hallowell, S Wake, K Alsop, M Gleeson, D Bowtell, G Mitchell, MA Young

2015-02-20

Population-based genetic research may produce information that has clinical implications for participants and their family. Resear..

Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer

FJ Candido-dos-Reis, H Song, EL Goode, JM Cunningham, BL Fridley, MC Larson, K Alsop, E Dicks, P Harrington, SJ Ramus, A De Fazio, G Mitchell, S Fereday, KL Bolton, C Gourley, C Michie, B Karlan, J Lester, C Walsh, I Cass

2015-02-01

The authors thank Craig Luccarini, the staff at the Eastern Cancer Registration and Information Centre (SEARCH); Alicia Barroso, V..

The responses of research participants and their next of kin to receiving feedback of genetic test results following participation in the Australian Ovarian Cancer Study

N Hallowell, K Alsop, M Gleeson, A Crook, L Plunkett, D Bowtell, G Mitchell, MA Young

2013-01-01

Purpose: The generation of clinically significant genetic data during research studies raises a number of ethical issues about the..